Ruoff H J, Sewing K F
Naunyn Schmiedebergs Arch Pharmacol. 1976 Aug;294(2):207-8. doi: 10.1007/BF00507855.
The activity of the non-stimulated, basal adenylate cyclase of the dog gastric mucosa is reduced by the histamine H2-receptor antagonist metiamide but not by the histamine H1-receptor antagonist mepyramine. Histamine activates the adenylate cyclase only slightly. In the presence of 10(-5) M metiamide a concentration-dependent stimulation of the enzyme by histamine was found. These data indicate that endogenous histamine in dog gastric mucosal homogenate is contributing at least in part to what is measured as "basal" adenylate cyclase activity. This effect is mediated by H2-receptor excitation and in earlier studies has prevented the demonstration of a stimulatory effect of exogenous histamine on this enzyme.
犬胃黏膜非刺激状态下的基础腺苷酸环化酶活性，可被组胺H2受体拮抗剂甲硫米特降低，但不会被组胺H1受体拮抗剂美吡拉敏降低。组胺对腺苷酸环化酶的激活作用微弱。在存在10⁻⁵M甲硫米特的情况下，发现组胺对该酶有浓度依赖性刺激作用。这些数据表明，犬胃黏膜匀浆中的内源性组胺至少部分促成了被测定为“基础”腺苷酸环化酶活性的物质。这种作用是由H2受体兴奋介导的，并且在早期研究中，这种作用妨碍了外源性组胺对该酶刺激作用的证明。
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