组胺及组胺类似物对大鼠胃腺苷酸环化酶的刺激作用以及布立马胺的阻断作用。
Stimulation of rat gastric adenylate cyclase by histamine and histamine analogues and blockade by burimamide.
作者信息
McNeil J H, Verma S C
出版信息
Br J Pharmacol. 1974 Sep;52(1):104-6. doi: 10.1111/j.1476-5381.1974.tb09694.x.
Abstract
Histamine, 4-methylhistamine, 3-(beta-aminoethyl)-1,2,4 triazole and betazole, in that order, stimulated adenylate cyclase prepared from rat gastric tissue in a dose-dependent manner. Burimamide, an H(2)-receptor blocking agent, in concentrations of 1-5 x 10(-6) M antagonized this effect. The data lend some support to the hypothesis that elevated levels of cyclic adenosine 3',5'-monophosphate may be involved in histamine-stimulated gastric secretions and that H(2)-receptors are associated with adenylate cyclase.
摘要
组胺、4-甲基组胺、3-(β-氨乙基)-1,2,4-三唑和倍他唑依次以剂量依赖方式刺激从大鼠胃组织制备的腺苷酸环化酶。H₂受体阻断剂布立马胺，浓度为1 - 5×10⁻⁶ M时可拮抗此效应。这些数据为以下假说提供了一些支持：即环磷酸腺苷水平升高可能参与组胺刺激的胃分泌，且H₂受体与腺苷酸环化酶有关。
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