情感障碍患者亚组中的锂红细胞/血浆比率。

Lithium RBC/plasma ratio in subgroups of patients with affective disorders.

作者信息

von Knorring L, Oreland L, Perris C, Runeberg S

出版信息

Neuropsychobiology. 1976;2(2-3):74-80. doi: 10.1159/000117533.

Abstract

The lithium RBC/plasma ratio was determined in 59 patients during prophylactic lithium therapy -- 10 cycloid psychotics, 28 unipolars and 21 bipolars -- as well as in 20 patients during lithium therapy in phase of illness -- 8 cycloid psychotics, 5 unipolars and 7 bipolars. The lithium ratio was found to be normally distributed both among patients in phase of remission and those in phase of illness. No differences in lithium ratio were found between patients in phase of remission and phase of illness, respectively. During prophylactic lithium therapy, no differences were found in the lithium ratio between patients in different diagnostic subgroups. In a correlation matrix, the lithium ratio was found to correlate to lithium in RBC but not to age, sex, type of illness, weight, lithium dosage, duration of treatment or level of lithium in plasma. The lithium level in RBC was determined only by the lithium level in plasma. Thus, the lithium RBC/plasma ratio does not seem to be of diagnostic value in affective disorders.

摘要

在59例接受锂盐预防性治疗的患者中测定了红细胞/血浆锂比值，其中包括10例循环型精神病患者、28例单相情感障碍患者和21例双相情感障碍患者；同时还在20例处于疾病发作期接受锂盐治疗的患者中进行了测定，其中包括8例循环型精神病患者、5例单相情感障碍患者和7例双相情感障碍患者。结果发现，无论是处于缓解期的患者还是处于疾病发作期的患者，锂比值均呈正态分布。处于缓解期和疾病发作期的患者之间，锂比值没有差异。在预防性锂盐治疗期间，不同诊断亚组的患者之间锂比值也没有差异。在一个相关矩阵中，发现锂比值与红细胞中的锂相关，但与年龄、性别、疾病类型、体重、锂剂量、治疗持续时间或血浆中的锂水平无关。红细胞中的锂水平仅由血浆中的锂水平决定。因此，红细胞/血浆锂比值在情感障碍中似乎没有诊断价值。