锂与抗精神病药物联合使用——对锂红细胞/血浆比率的影响。

Lithium and neuroleptic drugs in combination - effect on lithium RBC/plasma ratio.

作者信息

von Knorring L, Smigan L, Perris C, Oreland L

出版信息

Int Pharmacopsychiatry. 1982;17(4):287-92. doi: 10.1159/000468585.

Abstract

The lithium RBC/plasma ratio was determined in 59 patients during prophylactic lithium therapy. No relationship was found between the lithium RBC/plasma ratio and sex, age, type of illness, weight, lithium dosage, duration of treatment or lithium plasma level. However, patients taking a combination of lithium and neuroleptic drugs had significantly higher lithium RBC/plasma ratios than patients taking lithium without neuroleptic drugs. The results are in line with earlier in vitro studies and are discussed in relation to the high frequency of neurotoxic and nephrotoxic adverse effects noted in patients taking a combination of lithium and neuroleptic drugs.

摘要

在59例接受锂盐预防性治疗的患者中测定了红细胞/血浆锂比值。未发现红细胞/血浆锂比值与性别、年龄、疾病类型、体重、锂盐剂量、治疗时长或血浆锂水平之间存在关联。然而，同时服用锂盐和抗精神病药物的患者其红细胞/血浆锂比值显著高于仅服用锂盐的患者。这些结果与早期的体外研究一致，并结合服用锂盐和抗精神病药物的患者中神经毒性和肾毒性不良反应的高发生率进行了讨论。