Baranova L N, Aleksandrov V A
Biull Eksp Biol Med. 1978 Oct;86(10):477-9.
Rats were given 7,12-dimethylbenz(a)anthracene (DMBA) intravenously in a dose of 15 mg/kg on the 21st day of pregnancy; its content in the liver, placenta, and the fetus was determined by the fluorescent-spectral method. The maximal concentration was reached in 10--15 min in the liver and placenta of the pregnant rats (45 and 6.3 microgram/kg, respectively) in comparison with a slower (in one hour) elevation in the fetal tissues (2.4 microgram/kg). It took about 5 hours for all the tissues to be cleared of the carcinogen. One hour after the administration DMBA was unevenly distributed in various fetal organs--the maximal content in the liver, and the minimal--in the "carcass" in comparison with the content in other organs (the kidneys, lungs, brain, intestine). The results obtained failed to correlate with the data on the predominant origination of the tumours in the kidneys and the nervous system of rats in transplacental DMBA action.
在妊娠第21天，给大鼠静脉注射剂量为15mg/kg的7,12-二甲基苯并(a)蒽（DMBA）；采用荧光光谱法测定其在肝脏、胎盘和胎儿中的含量。与胎儿组织中较慢（1小时）升高至（2.4μg/kg）相比，妊娠大鼠的肝脏和胎盘在10-15分钟内达到最大浓度（分别为45和6.3μg/kg）。所有组织清除致癌物约需5小时。给药1小时后，DMBA在胎儿各器官中分布不均——与其他器官（肾脏、肺、脑、肠）相比，肝脏中含量最高，“躯体”中含量最低。所得结果与经胎盘给予DMBA时大鼠肾脏和神经系统肿瘤主要起源的数据不相关。
