Anisimov V N, Aleksandrov V A
Vopr Onkol. 1979;25(6):84-8.
Under study was the tritium distribution in tissues of the neuroendocrines system, liver and muscle after intravenous injection into female rats of an aqueous-lipid emulsion containing 3H-DMBA in a dose of 0.05 mci/kg. Thirty minutes following the injection the specific radioactivity of the liver, endocrinous glands, anterior and mediobasal hypothalamus tissues was higher than that of the cerebral cortex, dorsal hypothalamus. Label incorporation into the mediobasal hypothalamus was maintained at a higher level during 12 hours after 3N-DMBA administration than in the anterior and medial hypothalamus, cerebral cortex or muscle. A preliminary injection of adebit or I-DOPA failed to influence the character or rate of tritium uptake by tissues 30 minutes, after the labelled carcinogen was injected. The significance of DMBA retention in the hypothalamus for the mechanism of its action on the neuroendocrinous system is discussed.
研究了给雌性大鼠静脉注射剂量为0.05毫居里/千克、含3H-DMBA的水脂质乳剂后，氚在神经内分泌系统、肝脏和肌肉组织中的分布情况。注射后30分钟，肝脏、内分泌腺、下丘脑前区和下丘脑中间基底部组织的比放射性高于大脑皮层、下丘脑背侧部。给予3N-DMBA后12小时内，下丘脑中间基底部的标记物掺入水平高于下丘脑前区和内侧区、大脑皮层或肌肉。在注射标记致癌物30分钟后，预先注射阿的平或L-多巴未能影响组织摄取氚的特征或速率。文中讨论了DMBA在下丘脑中的潴留对其作用于神经内分泌系统机制的意义。
