Baranova L N, Aleksandrov V A
Biull Eksp Biol Med. 1980 Mar;89(3):334-5.
On the 21st day of pregnancy rats were injected intravenously with 7,12-dimethylbenz(a)anthracene (DMBA) in a dose of 15 mg/kg. After 30, 60 and 180 min the content of the preparation was determined by the fluorescent-spectral method in the organs of females (liver, kidneys, lungs, brain, spleen and placenta) and in their fetuses (liver, kidneys, lungs, brain, intestine, "carcasses" and intact fetus). In the course of all experimental periods the female rats showed the highest concentration of DMBA in the lungs. The concentration of DMBA in all organs of pregnant rats diminished while in the brain it increased with time elapsed after injection. The fetuses showed uneven distribution of the carcinogen in the organs only 60 min after DMBA injection, the highest content being recorded in the liver. The maximum content of the carcinogen was detected in all organs of the fetus by the 60th minute. DMBA accumulation in fetal organs did not correlate with the evidence on predominant occurrence of tumours in the kidneys and the nervous system of the progeny in transplacental effect of DMBA administered in the same dose.
在妊娠第21天，给大鼠静脉注射剂量为15毫克/千克的7,12-二甲基苯并(a)蒽（DMBA）。在注射后30、60和180分钟，通过荧光光谱法测定雌性大鼠（肝脏、肾脏、肺、脑、脾脏和胎盘）及其胎儿（肝脏、肾脏、肺、脑、肠道、“尸体”和完整胎儿）器官中该制剂的含量。在所有实验期间，雌性大鼠肺部的DMBA浓度最高。妊娠大鼠所有器官中的DMBA浓度均降低，而脑中的DMBA浓度则随着注射后时间的推移而增加。仅在注射DMBA 60分钟后，胎儿器官中致癌物的分布就不均匀，肝脏中的含量最高。到第60分钟时，在胎儿的所有器官中均检测到致癌物的最大含量。在相同剂量的DMBA经胎盘作用下，胎儿器官中DMBA的积累与后代肾脏和神经系统中肿瘤主要发生的证据无关。
