Long R G, Friedmann A I, James D G
Postgrad Med J. 1976 Nov;52(613):689-92. doi: 10.1136/pgmj.52.613.689.
Thirty consecutive patients with severe scleritis or episcleritis were admitted as in-patients to the Medical Ophthalmology Unit and assessed for systemic disease. There were seventeen women and thirteen men. The mean age was 53 with a median of 57 (range 23-83). Eighteen of the patients had scleritis: eleven of these had evidence of connective tissue disease and three of them had temporal arteritis. Twelve patients had episcleritis: six of them had a collagen disease and one of them developed temporal arteritis. This high incidence of temporal arteritis in association with scleritis has not been previously reported. It is important to diagnose and treat overt temporal arteritis early with parenteral steroids so that ischaemic papillopathy can be avoided. A higher incidence of collagen diseases than previously described is reported in episcleritis. It is thought that this is secondary to selection since patients with the usual self-limiting episcleritis are not normally referred for further in-patient investigation. In no patient was more than one significant diagnosis made. There was no significant medical illness in only 11% of patients with scleritis and 33% of patients with episcleritis. The majority of the non-collagen diseases (e.g. hypertension) were not previously recognized. In none of the patients with temporal arteritis was the diagnosis made before admission. It is concluded that full examination and investigation for underlying disease is indicated in both scleritis and severe episcleritis.
连续30例患有严重巩膜炎或表层巩膜炎的患者被收治入住眼科内科病房,并接受全身疾病评估。其中有17名女性和13名男性。平均年龄为53岁,中位数为57岁(范围23 - 83岁)。18例患者患有巩膜炎:其中11例有结缔组织病的证据,3例有颞动脉炎。12例患者患有表层巩膜炎:其中6例有胶原病,1例发展为颞动脉炎。此前尚未报道过与巩膜炎相关的颞动脉炎的如此高发病率。早期用胃肠外类固醇诊断和治疗明显的颞动脉炎很重要,这样可以避免缺血性视乳头病变。据报道,表层巩膜炎中胶原病的发病率比以前描述的更高。认为这是选择的结果,因为通常自限性表层巩膜炎的患者通常不会被转诊进行进一步的住院检查。没有一位患者被做出超过一项重大诊断。在巩膜炎患者中只有11%、表层巩膜炎患者中只有33%没有明显的内科疾病。大多数非胶原病(如高血压)以前未被识别。在所有颞动脉炎患者中,入院前均未做出诊断。结论是,对于巩膜炎和严重表层巩膜炎,都需要对潜在疾病进行全面检查和调查。