Alpert S, Ghossein N A, Stacey P, Migliorelli F A, Efron G, Krishnaswamy V
Cancer. 1978 Oct;42(4):2054-8. doi: 10.1002/1097-0142(197810)42:4<2054::aid-cncr2820420456>3.0.co;2-7.
109 cases of breast cancer were treated by tumorectomy and radiotherapy or radiotherapy alone. Almost 30% with small tumors (T1, T2) were considered inoperable for medical reasons and 70% refused mastectomy. Over the past five years the number of patients refusing mastectomy has definitely increased. 59 cases of surgically resectable cancers (T1, T2, T3, N0, N1) had a minimum followup of two years (average 4 years +/- 3 months). Absolute and determinate survivals NED were 65% and 86%. There were four local recurrences (8%). Secondary mastectomy could be performed on three. Microscopic involvement of the surgical margin by cancer did not alter the local control rate. The cosmetic results were good in 98%. Gross removal of the tumor followed by radiotherapy may be offered as an alternative to mastectomy in patients with operable breast cancer.
109例乳腺癌患者接受了肿瘤切除术及放疗或单纯放疗。近30%的小肿瘤（T1、T2）患者因医学原因被认为无法手术，70%的患者拒绝乳房切除术。在过去五年中，拒绝乳房切除术的患者数量明显增加。59例可手术切除的癌症患者（T1、T2、T3、N0、N1）至少随访了两年（平均4年±3个月）。无疾病证据（NED）的绝对生存率和确定生存率分别为65%和86%。有4例局部复发（8%）。其中3例可行二期乳房切除术。手术切缘有癌的显微镜下累及情况并未改变局部控制率。98%的患者美容效果良好。对于可手术的乳腺癌患者，肿瘤大块切除后放疗可作为乳房切除术的替代方案。
