Martinez A, Clarke D
West J Med. 1983 May;138(5):676-80.
Between May 1973 and December 1980 there were 76 patients (78 breasts) with clinical stage I or II breast carcinoma treated by biopsy and definitive radiotherapy at Stanford University Medical Center. Local-regional control has been achieved thus far in 76 of 78 cases (97 percent) with a median follow-up time of 26 months. Transient lymphedema of the breast, arm edema and breast fibrosis were the most commonly noted complications. The cosmetic result was analyzed and scored as excellent in 78 percent, satisfactory in 18 percent and unsatisfactory in 4 percent. The three unsatisfactory results occurred in patients in whom severe fibrosis developed as a result of suboptimal radiation techniques. Interdisciplinary cooperation among surgical, medical and radiation oncologists is important. The 97 percent local-regional control and the 96 percent excellent-to-satisfactory results support the use of primary radiotherapy in early stage breast carcinoma.
1973年5月至1980年12月期间，斯坦福大学医学中心对76例（78个乳房）临床I期或II期乳腺癌患者进行了活检及根治性放疗。截至目前，78例中有76例（97%）实现了局部区域控制，中位随访时间为26个月。乳房短暂性淋巴水肿、手臂水肿和乳房纤维化是最常见的并发症。对美容效果进行了分析，78%的结果为优秀，18%为满意，4%为不满意。这三个不满意的结果出现在因放疗技术欠佳而出现严重纤维化的患者中。外科、内科和放疗肿瘤学家之间的跨学科合作很重要。97%的局部区域控制率以及96%的优秀至满意结果支持在早期乳腺癌中使用原发性放疗。
