儿茶酚雌激素的便捷大规模制备。
Convenient large scale preparation of catechol estrogens.
作者信息
Stubenrauch G, Knuppen R
出版信息
Steroids. 1976 Nov;28(5):733. doi: 10.1016/0039-128x(76)90010-6.
PMID:1014044
Abstract
2-Hydroxyestrone, 2-hydroxyestradiol-17beta, 2-hydroxy-17alpha-ethynylestradiol, 2-hydroxyestriol, 4-hydroxyestrone, 4-hydroxyestradiol-17beta, 4-hydroxy-17alpha-ethynylestradiol and 4-hydroxyestriol are prepared on a preparative scale from the corresponding aminophenols using a new inverse oxidation procedure. By the synthesis described both the 2- and 4-hydroxylated estrogens are available in high yields.
摘要
使用一种新的反向氧化程序，从相应的氨基酚出发，以制备规模制备了2-羟基雌酮、2-羟基雌二醇-17β、2-羟基-17α-乙炔基雌二醇、2-羟基雌三醇、4-羟基雌酮、4-羟基雌二醇-17β、4-羟基-17α-乙炔基雌二醇和4-羟基雌三醇。通过所述合成方法，2-羟基化和4-羟基化雌激素均能以高收率获得。
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