单核细胞增多性李斯特菌感染豚鼠后获得性细胞抗性、迟发型超敏反应及巨噬细胞迁移改变
Acquired cellular resistance, delayed hypersensitivity, and altered macrophage migration in Listeria monocytogenes-infected guinea pigs.
作者信息
Dustoor M M, Blazkovec A A
出版信息
Infect Immun. 1978 Jul;21(1):10-6. doi: 10.1128/iai.21.1.10-16.1978.
A Listeria monocytogenes infection in guinea pigs was used to study the interrelationship between antigen-induced macrophage migration inhibition, delayed-type hypersensitivity, and acquired cellular resistance. Early after infection (at 2 and 7 days), very significant enhancement of macrophage migration was observed. Migration inhibition was detected beginning on day 14 and was uniformly observed only on day 21 of the infection, after which a shift again to enhancement was seen. The early detection (by day 2) of migration enhancement suggested that this assay may be more sensitive than assessment of delayed type hypersensitivity in vivo, which in this system was first detectable only on day 4. Acquired cellular resistance, as measured by enhanced survival following a high dose challenge with Listeria, was present from day 7 after infection until at least day 60. By splenic clearance studies, however, acquired cellular resistance was present only until day 14 after infection, suggesting that in this system splenic clearance was not a very reliable criterion for measuring acquired cellular resistance.
利用豚鼠单核细胞增生李斯特菌感染来研究抗原诱导的巨噬细胞迁移抑制、迟发型超敏反应和获得性细胞抗性之间的相互关系。感染后早期（第2天和第7天），观察到巨噬细胞迁移显著增强。从第14天开始检测到迁移抑制，且仅在感染第21天一致观察到，之后又再次出现增强。迁移增强的早期检测（第2天）表明，该检测方法可能比体内迟发型超敏反应评估更敏感，在该系统中迟发型超敏反应最早在第4天才能检测到。通过高剂量李斯特菌攻击后存活率提高来衡量的获得性细胞抗性，从感染后第7天直至至少第60天都存在。然而，通过脾脏清除研究，获得性细胞抗性仅在感染后第14天之前存在，这表明在该系统中脾脏清除不是衡量获得性细胞抗性的非常可靠的标准。
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