在延迟足垫反应部位增强单核细胞增生李斯特菌的清除。
Enhanced elimination of Listeria monocytogenes at the site of delayed footpad reaction.
作者信息
Mitsuyama M, Nomoto K, Akeda H, Takeya K
出版信息
Infect Immun. 1980 Oct;30(1):1-4. doi: 10.1128/iai.30.1.1-4.1980.
Abstract
The protective activity against a challenge infection with Listeria monocytogenes was investigated at the site of a delayed footpad reaction in mice immunized with viable or killed listeria. Delayed footpad reactivity was induced only in mice immunized with viable bacteria. Rapid and marked elimination of challenge bacteria was observed only at the site of reaction in mice immunized with viable bacteria but not in mice immunized with killed bacteria. Macrophage migration inhibitory activity was observed equally in both groups of mice. These results suggest that the delayed footpad reaction contributes directly to the elimination of bacteria irrespective of macrophage migration inhibitory activity.
摘要
在用活的或灭活的李斯特菌免疫的小鼠中，在迟发型足垫反应部位研究了对单核细胞增生李斯特菌攻击感染的保护活性。仅在用活细菌免疫的小鼠中诱导出迟发型足垫反应性。仅在用活细菌免疫的小鼠的反应部位观察到攻击细菌的快速和显著清除，而在用灭活细菌免疫的小鼠中未观察到。在两组小鼠中均观察到同等程度的巨噬细胞移动抑制活性。这些结果表明，迟发型足垫反应直接有助于细菌的清除，而与巨噬细胞移动抑制活性无关。
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