Palcoux J B, Meyer M, Jouanel P, Tridon A, Vanlieferinghen P, Carla H, Malpuech G
Department of Paediatrics, Faculté de Médecine, Clermont-Ferrand, France.
Transfus Sci. 1993 Oct;14(4):423-7. doi: 10.1016/S0955-3886(05)80017-7.
Two girls with familial hypercholesterolemia were treated for 7 years by plasma exchanges (PE) or LDL-apheresis (LA). We compared different methods of treatment; PE with or without reuse of the plasma separator, LA of varying frequency, and LA with or without oral administration of simvastatin. We assessed the long-term results by measuring the blood levels of the biochemical parameters before sessions, and determined the effectiveness of each session by the percentage of decrease in the blood levels between the beginning and the end of the sessions. LA led to a more selective treatment (lowering of LDL cholesterol and maintenance of HDL cholesterol), but the blood levels of total cholesterol before sessions were the same as those obtained by PE. IgG and haemoglobin levels decreased little with LA. The rhythm of one session a week gave better results in LA. Although reuse of the plasma separator represents a financial saving it produced poorer results. The oral administration of simvastatin improved the results of LA.
两名家族性高胆固醇血症女孩接受了7年的血浆置换（PE）或低密度脂蛋白清除术（LA）治疗。我们比较了不同的治疗方法：使用或不使用血浆分离器重复使用的PE、不同频率的LA，以及使用或不使用口服辛伐他汀的LA。我们通过测量治疗前生化参数的血液水平来评估长期结果，并通过疗程开始和结束时血液水平下降的百分比来确定每个疗程的有效性。LA导致了更具选择性的治疗（降低低密度脂蛋白胆固醇并维持高密度脂蛋白胆固醇），但治疗前的总胆固醇血液水平与PE所获得的水平相同。LA治疗后IgG和血红蛋白水平下降很少。LA每周进行一次治疗的效果更好。虽然血浆分离器的重复使用节省了费用，但效果较差。口服辛伐他汀改善了LA的治疗效果。
