Kawanabe K, Tamura J, Yamamuro T, Nakamura T, Kokubo T, Yoshihara S
Department of Orthopedic Surgery, Faculty of Medicine, Kyoto University, Japan.
J Appl Biomater. 1993 Summer;4(2):135-41. doi: 10.1002/jab.770040204.
We have developed a bioactive bone cement consisting of silane-treated CaO-SiO 2-P 2O 5-CaF 2 glass powder as the filling particles and bisphenol-a-glycidyl methacrylate (BIS-GMA) diluted with triethylene-glycol dimethacrylate (TEGDMA) as the organic matrix. Histological examination demonstrated direct bonding between the cement and bone along the circumference of the cement at 4 weeks after implantation in rat tibia. The compressive strength and toughness of the cement were two and four times greater than those of polymethylmethacrylate (PMMA) cement, respectively. The inflammatory reaction of the skin caused by the new cement was not as intense as that for PMMA 3 days after subcutaneous implantation. This new cement may be applicable as a bioactive bone cement with high mechanical strength.
我们研发了一种生物活性骨水泥，其由硅烷处理的CaO-SiO₂-P₂O₅-CaF₂玻璃粉末作为填充颗粒，以及用三乙二醇二甲基丙烯酸酯（TEGDMA）稀释的双酚A-甲基丙烯酸缩水甘油酯（BIS-GMA）作为有机基质组成。组织学检查表明，在大鼠胫骨植入后4周，骨水泥与骨沿骨水泥圆周处直接结合。该骨水泥的抗压强度和韧性分别是聚甲基丙烯酸甲酯（PMMA）骨水泥的两倍和四倍。皮下植入3天后，新型骨水泥引起的皮肤炎症反应不如PMMA强烈。这种新型骨水泥有望作为一种具有高机械强度的生物活性骨水泥应用。
