Department of Orthopaedic and Trauma Surgery, University of Oulu, FIN-90014, Oulu, Finland.
J Mater Sci Mater Med. 2010 May;21(5):1677-84. doi: 10.1007/s10856-010-4017-5. Epub 2010 Feb 17.
Bioactive glasses have been developed as scaffolds for bone tissue engineering but combination with reindeer bone protein extract has not been evaluated. We investigated the effects of bone protein extract implants (5-40 mg dosages) with bioglass (BG) carrier on the healing of rat femur defects. Bioglass implants and untreated defects served as controls. All doses of extract increased bone formation compared with the control groups, and bone union was enhanced with doses of 10 mg or more. In comparison with untreated defect, mean cross-sectional bone area at the defect site was greater when implants with BG + 15 mg of extract or bioglass alone were used, bone density at the defect site was higher in all bioglass groups with and without bone extract, and the BG + 15 mg extract dosage marginally increased bone torsional stiffness in mechanical testing. Bioglass performed well as a carrier candidate for reindeer bone protein extract.
生物活性玻璃已被开发为骨组织工程的支架，但与驯鹿骨蛋白提取物的结合尚未得到评估。我们研究了骨蛋白提取物植入物（5-40mg 剂量）与生物玻璃（BG）载体结合对大鼠股骨缺损愈合的影响。生物玻璃植入物和未处理的缺损作为对照。与对照组相比，所有剂量的提取物都增加了骨形成，并且 10mg 或更高剂量的提取物增强了骨融合。与未处理的缺损相比，当使用含有 15mg 提取物或单独生物玻璃的植入物时，在缺损部位的平均横截面骨面积更大，在有和没有骨提取物的所有生物玻璃组中，在缺损部位的骨密度更高，并且 BG+15mg 提取物剂量略微增加了机械测试中的骨扭转刚度。生物玻璃作为驯鹿骨蛋白提取物的载体候选物表现良好。
