DeLaney T F, Smith P D, Thomas G F, Tochner Z A, Sindelar W F, Pass H I, Harrington F S, Bonner R F, Mitchell J B
Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
J Clin Laser Med Surg. 1991 Oct;9(5):361-6. doi: 10.1089/clm.1991.9.361.
Light delivery to anatomic areas involved by tumor is critical for effective photodynamic therapy. The authors provide a detailed overview of a light-diffusing device which they have used for intraoperative illumination of the peritoneal and pleural cavities in patients with tumors involving the surfaces of these cavities. Their device represents an inexpensive modification of widely available endotracheal tubes. It has been used to deliver intraoperative photodynamic therapy in over 50 patients without episodes of device failure. When combined with a lipid-based, light-diffusing medium and on-line power/energy density monitoring, it allows homogeneous illumination of these complex surfaces.
将光传递到肿瘤所累及的解剖区域对于有效的光动力治疗至关重要。作者详细概述了一种光扩散装置，他们已将其用于术中照亮肿瘤累及腹膜腔和胸膜腔表面的患者的这些腔隙。他们的装置是对广泛使用的气管导管进行的一种低成本改造。它已用于超过50例患者的术中光动力治疗，且无装置故障发生。当与基于脂质的光扩散介质和在线功率/能量密度监测相结合时，它能够对这些复杂表面进行均匀照明。
