Pass H I, Donington J S
Thoracic Oncology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Semin Surg Oncol. 1995 Sep-Oct;11(5):360-7. doi: 10.1002/ssu.2980110506.
Photodynamic therapy (PDT) is a surface oriented, locally cytotoxic intervention being investigated for oncologic therapy. Surfaces such as the pleura or the peritoneum are frequently involved with primary or metastatic cancer, and the chance for cure in such situations is low due to the inability to eradicate all the disease. A series of investigations have been performed at the National Cancer Institute since 1985 studying the possible use of PDT for large cavity treatment. This report details evolution of the methodology, toxicity, and overall feasibility of the delivery of intrapleural PDT to patients after debulking of primary and malignant chest neoplasms, with an emphasis on malignant pleural mesothelioma. These investigations have culminated in an ongoing Phase III trial to define the efficacy of intrapleural PDT.
光动力疗法（PDT）是一种面向表面的局部细胞毒性干预措施，正在作为肿瘤治疗方法进行研究。诸如胸膜或腹膜等表面经常受到原发性或转移性癌症的影响，由于无法根除所有疾病，在这种情况下治愈的机会很低。自1985年以来，美国国家癌症研究所进行了一系列研究，探讨光动力疗法用于大腔治疗的可能性。本报告详细介绍了在对原发性和恶性胸部肿瘤进行减瘤手术后，对患者进行胸膜内光动力疗法的方法演变、毒性和总体可行性，重点是恶性胸膜间皮瘤。这些研究最终促成了一项正在进行的III期试验，以确定胸膜内光动力疗法的疗效。
