Gipson I K, Inatomi T
Schepens Eye Research Institute, Boston, Massachusetts, USA.
Curr Opin Ophthalmol. 1995 Aug;6(4):3-10. doi: 10.1097/00055735-199508000-00002.
Healing of corneal wounds is a complex process involving epithelial, keratocyte, and endothelial interactions that are affected by their associations with wound bed matrix and by cytokine availability and activation. The spectrum of possible cellular-matrix-growth factor interactions is indeed great and growing. Several of the significant contributions made during the past year include development of an organotypic organ culture model of the cornea that allows in vitro assembly of the epithelial extracellular matrix-anchoring complex, demonstration of epithelial synthesis of Bowman's layer collagens, demonstration of transforming growth factor-beta 2's inhibition of stromal cell collagenase synthesis, and demonstration of the paracrine pathway of keratinocyte growth factor action in the cornea.
角膜伤口愈合是一个复杂的过程，涉及上皮细胞、角膜细胞和内皮细胞的相互作用，这些相互作用会受到它们与伤口床基质的关联以及细胞因子的可用性和激活的影响。细胞-基质-生长因子之间可能的相互作用范围确实很广，而且还在不断扩大。过去一年里取得的一些重要成果包括：开发了一种角膜器官型器官培养模型，该模型能够在体外组装上皮细胞外基质锚定复合体；证明了上皮细胞能合成Bowman层胶原蛋白；证明了转化生长因子-β2可抑制基质细胞胶原酶的合成；以及证明了角质形成细胞生长因子在角膜中作用的旁分泌途径。
