Nishida T, Tanaka T
Yamaguchi University School of Medicine, Department of Ophthalmology, Japan.
Curr Opin Ophthalmol. 1996 Aug;7(4):2-11. doi: 10.1097/00055735-199608000-00002.
The crystal clear cornea has been challenged by refractive surgeries. The surgical outcome depends on the healing responses of the cornea. The factors responsible for the corneal wound healing have been characterized. The orchestrated action of extracellular matrix proteins, growth factors, cytokines, and their receptors have been investigated extensively over the past decade. The clinical results with refractive surgeries provide us various important information with regard to the physiology and pathology of the cornea. The role of basement membrane or Bowman's membrane is now challenged for the maintenance and repair of the epithelium. Furthermore, the interactions between epithelium and stroma is another field to be investigated. The regulatory mechanisms of the maintenance of stromal collagen by keratocytes is also studied. This review discusses the current advancement in the healing responses of the cornea to various injuries and refractive surgeries.
晶莹剔透的角膜一直面临着屈光手术的挑战。手术结果取决于角膜的愈合反应。导致角膜伤口愈合的因素已得到明确。在过去十年中，细胞外基质蛋白、生长因子、细胞因子及其受体的协同作用得到了广泛研究。屈光手术的临床结果为我们提供了有关角膜生理和病理的各种重要信息。现在，基底膜或Bowman膜在上皮维持和修复中的作用受到了挑战。此外，上皮与基质之间的相互作用是另一个有待研究的领域。角膜细胞维持基质胶原的调节机制也在研究中。本综述讨论了角膜对各种损伤和屈光手术愈合反应的当前进展。
