Konnov B A, Karlin D L, Konnova L A, Kadyrova N O, Gubareva A V
Radiobiologiia. 1988 Nov-Dec;28(6):822-8.
In experiments with rats a study was made of the radiobiological influence of a pulse frequency (45.9 and 4.5 c-1) of a 1000 MeV proton beam. The estimates of metabolic parameters of the peripheral blood and spleen 24 h and the survival rate during 60 days following irradiation have demonstrated the increase in the biological effectiveness of the proton beam with decreasing pulse frequency. As to 60Co-gamma-radiation, RBE of protons was 1.10 +/- 0.04 at the pulse frequency of 9 c-1 and 0.98 +/- 0.03 at 45 c-1 as determined by the probit-logarithm dose method.
在对大鼠的实验中，研究了1000兆电子伏特质子束的脉冲频率（45.9和4.5次/秒）的放射生物学影响。对照射后24小时外周血和脾脏的代谢参数估计以及60天内的存活率表明，随着脉冲频率降低，质子束的生物有效性增加。至于60Co-γ辐射，通过概率对数剂量法测定，在脉冲频率为9次/秒时质子的相对生物效应（RBE）为1.10±0.04，在45次/秒时为0.98±0.03。
