Johannesson M
Centre for Health Economics, Stockholm School of Economics, Sweden.
Pharmacoeconomics. 1995 Mar;7(3):242-50. doi: 10.2165/00019053-199507030-00008.
The aim of this study was to carry out an analysis of the cost effectiveness of antihypertensive drug treatment in different patient groups in Sweden. The cost-effectiveness ratios were estimated as net costs (treatment costs minus reduced costs of cardiovascular morbidity) divided by the number of life-years gained (the increase in life expectancy). The analysis was based on the reduction of coronary heart disease and stroke in the most recent meta-analysis of antihypertensive treatment, to which Swedish cost data were applied. We found that the cost per life-year gained decreases with age for both men and women, and is relatively low for middle-aged and older patients, even when the diastolic blood pressure (DBP) range is 90 to 94mm Hg. In conclusion, the results indicate that, in Sweden, antihypertensive treatment is generally cost effective in middle-aged and older patients with a DBP of > or = 90 mm Hg. However, it is questionable whether it is generally cost effective to treat younger patients with mild hypertension.
本研究的目的是对瑞典不同患者群体中抗高血压药物治疗的成本效益进行分析。成本效益比的估算方法是净成本(治疗成本减去心血管疾病发病率降低带来的成本)除以获得的生命年数(预期寿命的增加)。该分析基于抗高血压治疗最新荟萃分析中冠心病和中风的减少情况,并应用了瑞典的成本数据。我们发现,男性和女性每获得一个生命年的成本均随年龄增长而降低,对于中年和老年患者而言,该成本相对较低,即使舒张压(DBP)范围为90至94毫米汞柱时也是如此。总之,结果表明,在瑞典,对于舒张压≥90毫米汞柱的中年和老年患者,抗高血压治疗总体上具有成本效益。然而,对于轻度高血压的年轻患者进行治疗总体上是否具有成本效益仍值得怀疑。