Patterson R, Orange R, Harris K E
J Allergy Clin Immunol. 1978 Dec;62(6):371-7. doi: 10.1016/0091-6749(78)90139-2.
Slow-reacting substance of anaphylaxis (SRS-A) generated from rat peritoneal mast cells was aerosolized to the airways of a group of rhesus monkeys with established airway responses to ascaris antigen. A selective effect of SRS-A on pulmonary resistance and a lesser but significant effect on compliance was observed which differed from antigen, histamine, carbocholine, or prostaglandin (PG) F2alpha responses. The airway recovery from the PR change is slower than that from histamine and simulated PGF2alpha and some antigen experiments. The cutaneous reactions in rhesus monkeys due to SRS-A could be blocked in a dose response pattern by FPL55712 which did not affect histamine responses in rhesus skin.
将从大鼠腹膜肥大细胞产生的过敏反应慢反应物质（SRS-A）雾化到一组对蛔虫抗原有气道反应的恒河猴气道中。观察到SRS-A对肺阻力有选择性作用，对顺应性有较小但显著的作用，这与抗原、组胺、卡巴胆碱或前列腺素（PG）F2α反应不同。从肺阻力变化中恢复气道的速度比组胺、模拟PGF2α和一些抗原实验的恢复速度慢。FPL55712可以剂量反应模式阻断恒河猴因SRS-A引起的皮肤反应，而FPL55712不影响恒河猴皮肤中的组胺反应。
