不同疾病状态下发育中的人类小脑皮质的定量形态学研究。
Quantitative morphological studies of developing human cerebellar cortex in various disease states.
作者信息
Gadson D R, Emery J L
出版信息
Arch Dis Child. 1976 Dec;51(12):964-7. doi: 10.1136/adc.51.12.964.
Abstract
A quantitative morphological assessment was carried out of the cellularity and staining properties of the cells of the layers of the human cerebellar cortex, both in the normal child and in 41 children suffering from a series of disorders including mental retardation. A computerized image analyser and highly standardized procedures were used. All of the cases of mental retardation and some cases with congenital cardiac anomalies showed abnormal cell concentrations and staining properties. 3 cases of 'cot death' also showed abnormal results. These findings are presented as a new measurable aspect of brain disease, and as a indication for further study.
摘要
对正常儿童以及41名患有包括智力迟钝在内的一系列疾病的儿童的小脑皮质各层细胞的细胞密度和染色特性进行了定量形态学评估。使用了计算机图像分析仪和高度标准化的程序。所有智力迟钝病例以及一些先天性心脏异常病例均显示出细胞浓度和染色特性异常。3例“婴儿猝死综合征”病例也显示出异常结果。这些发现作为脑部疾病一个新的可测量方面以及进一步研究的一个指标被呈现出来。
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