Montoya J P, Merz S I, Bartlett R H
MC3, Inc., Ann Arbor, Michigan 48103, USA.
J Extra Corpor Technol. 1996 Jun;28(2):71-8.
A prototype of a non-occlusive pressure-regulated blood pump (M-pump) was evaluated in-vitro for safety in a comparative study with the roller and centrifugal pumps. The M-pump consists of collapsible tubing of unique design wrapped under tension around a rotor without a stator. The prototype M-pumps were tested in vitro to evaluate performance with respect to flow/ pressure characteristics, hemolysis, bubble generation (cavitation) and durability. The M-pump and centrifugal pump did not overpressurize at any RPM when the pump outlet was occluded, but the roller pump reached pressures in excess of 1000 mmHg. The M-pump did not generate negative pressures upon occlusion of the inlet, whereas the roller and centrifugal pumps produced near-vacuum pressures. Furthermore, the M-pump was unable to empty a blood reservoir when the height of the pump inlet was placed slightly above the reservoir outlet. The levels of microbubbles in the M-pump were significantly lower than the roller and centrifugal pumps upon sudden restriction of the pump inlet as determined with an ultrasonic bubble detector. The results of our in-vitro evaluation of the M-pump have shown it to have lower hemolysis than the centrifugal pump and lower or comparable hemolysis to roller pumps at flowrates of 0.1, 0.5, 4.0 and 6 L/min. We determined that the M-pump design possesses important safety advantages over roller and centrifugal pumps for cardiopulmonary bypass applications.
在一项与滚压泵和离心泵的对比研究中，对一种非阻塞性压力调节血泵（M泵）的原型进行了体外安全性评估。M泵由一种设计独特的可折叠管道组成，该管道在张力作用下缠绕在一个无定子的转子周围。对M泵原型进行了体外测试，以评估其在流量/压力特性、溶血、气泡产生（空化）和耐用性方面的性能。当泵出口被阻塞时，M泵和离心泵在任何转速下都不会出现过压情况，但滚压泵的压力超过了1000 mmHg。当入口被阻塞时，M泵不会产生负压，而滚压泵和离心泵会产生接近真空的压力。此外，当泵入口高度略高于储液器出口时，M泵无法排空储血器。用超声波气泡探测器测定，在泵入口突然受限的情况下，M泵中的微气泡水平明显低于滚压泵和离心泵。我们对M泵的体外评估结果表明，在0.1、0.5、4.0和6 L/min的流速下，其溶血程度低于离心泵，与滚压泵相比溶血程度更低或相当。我们确定，对于体外循环应用，M泵的设计相对于滚压泵和离心泵具有重要的安全优势。
