Tsuchiya T, Nakamura A
Division of Medical Devices, National Institute of Health Sciences, Tokyo, Japan.
J Long Term Eff Med Implants. 1995;5(4):233-42.
A possible mechanism of tumorigenesis induced by the polyetherurethanes (PEUs) is clarified as follows: the tumor-promoting activities of the PEUs were stronger than the initiating activities; the promotion was facilitated by the polyether soft segment moiety such as poly (tetramethylene oxide) (PTMO), resulting in the inhibition of the gap-junctional intercellular communication; this inhibition was caused by leachable oligomers, degradation, and direct cell/material interaction. On the basis of our recent studies, we also propose a new hypothesis that inhibitory potentials of the intercellular communication play an important role on the tumor-promoting stage in various biomaterials.
聚醚聚氨酯（PEU）诱发肿瘤发生的一种可能机制如下：PEU的促肿瘤活性强于引发活性；聚醚软链段部分（如聚四氢呋喃（PTMO））促进了这种促进作用，导致细胞间缝隙连接通讯受到抑制；这种抑制是由可浸出的低聚物、降解以及细胞与材料的直接相互作用引起的。基于我们最近的研究，我们还提出了一个新的假说，即细胞间通讯的抑制潜能在各种生物材料的促肿瘤阶段起着重要作用。
