Nakaoka R, Tsuchiya T, Nakamura A
National Institute of Health Sciences, Tokyo, Japan.
J Long Term Eff Med Implants. 1995;5(4):253-62.
Tumor-promoting activity, inhibitory activity on the gap-junctional intercellular communication of polyethylene (PE) film containing a model antioxidant, 2,2'-methylene-bis(4-methyl-6-tert-butylphenol) (MBMBP), at various amounts was assessed by V79 metabolic cooperation (MC) assay. The extracts prepared from PE film containing MBMBP showed the inhibitory activities and the potencies of the inhibitory activities depended on the amount of MBMBP involved in the film, whereas the extract prepared from MBMBP-free PE film did not show any inhibitory activities. However, the inhibitory activities were observed when MC assay was carried out on the surface of the MBMBP-free film. These findings indicate that tumor-promoting activity of PE film is influenced by the surface property of the film as well as by amount and kind of additives incorporated.
通过V79代谢合作（MC）试验评估了含有模型抗氧化剂2,2'-亚甲基双（4-甲基-6-叔丁基苯酚）（MBMBP）的不同含量聚乙烯（PE）薄膜的促肿瘤活性及对间隙连接细胞间通讯的抑制活性。从含有MBMBP的PE薄膜制备的提取物显示出抑制活性，且抑制活性的强度取决于薄膜中MBMBP的含量，而从不含MBMBP的PE薄膜制备的提取物未显示出任何抑制活性。然而，当在不含MBMBP的薄膜表面进行MC试验时，观察到了抑制活性。这些发现表明，PE薄膜的促肿瘤活性受薄膜表面性质以及所掺入添加剂的数量和种类的影响。
