Lanes S F, Birmann B M, Walker A M, Sheffer A L, Rosiello R A, Lewis B E, Dreyer N A
Epidemiology Resources Inc., Newton Lower Falls, Massachusetts, USA.
Pharmacoeconomics. 1996 Oct;10(4):378-85. doi: 10.2165/00019053-199610040-00006.
In order to characterise asthma management in a managed care setting, we identified 10,301 patients who were diagnosed with asthma between 1 January 1988 and 31 December 1991 at a group model health maintenance organisation in central Massachusetts, US. We obtained for these patients automated utilisation files containing data on medications, hospitalisations, emergency room visits, office visits, and estimated costs of these services. The medication dispensed to the greatest proportion of patients was beta 2 agonists either by inhalation (56%) or orally (21%). Theophylline was dispensed to 23% of the patients. Maintenance therapy was inhaled anti-inflammatory medication was uncommon, as inhaled corticosteroids (17%) and sodium cromoglycate (cromolyn sodium) [8%] were dispensed to fewer patients than other asthma medications. Among patients who had been hospitalised in the previous year, 36% were presently receiving inhaled corticosteroids, and among patients who used at least one beta 2 agonist metered-dose inhaler per month, 49% were presently receiving inhaled corticosteroids. Economic analyses showed that only 8% of the patients had either a hospital admission or an emergency room visit, but hospital costs among these patients accounted for 25% of the total costs of asthma care. In addition, the top 10% most expensive patients accounted for 42% of the total cost of asthma care. We conclude that a substantial proportion of patients at increased risk of a severe attack, by virtue of having a recent hospitalisation, do not receive maintenance anti-inflammatory therapy, and that hospitalisations among a relatively small proportion of asthma patients contribute significantly to the cost of asthma care.
为了描述管理式医疗环境中的哮喘管理情况,我们在美国马萨诸塞州中部的一家团体模式健康维护组织中,确定了1988年1月1日至1991年12月31日期间被诊断为哮喘的10301名患者。我们为这些患者获取了自动化利用文件,其中包含药物、住院、急诊室就诊、门诊就诊以及这些服务的估计费用的数据。给最大比例患者配发的药物是吸入型(56%)或口服型(21%)的β2激动剂。23%的患者配发了茶碱。维持治疗使用吸入型抗炎药物的情况并不常见,因为吸入型糖皮质激素(17%)和色甘酸钠(8%)的配发患者比其他哮喘药物少。在上一年住院的患者中,36%目前正在接受吸入型糖皮质激素治疗;在每月至少使用一次β2激动剂定量气雾剂的患者中,49%目前正在接受吸入型糖皮质激素治疗。经济分析表明,只有8%的患者有过住院或急诊室就诊,但这些患者的住院费用占哮喘护理总费用的25%。此外,费用最高的前10%患者占哮喘护理总费用的42%。我们得出结论,相当一部分因近期住院而有严重发作风险增加的患者没有接受维持抗炎治疗,并且相对少数哮喘患者的住院对哮喘护理费用有显著贡献。