Bennett E J, Ignacio A, Patel K, Grundy E M, Salem M R
Br J Anaesth. 1976 Jul;48(7):687-9. doi: 10.1093/bja/48.7.687.
Tubocurarine, given as a single bolus, may be used safely for neuromuscular blockade in the neonate. The recommended dose is 250 mug/kg at birth, increasing to 500 mug/kg at 28 days of age. This dose should be reduced in the event of prematurity, acidosis or hypothermia, or when certain antibiotics or inhalation anaesthetic agents are present in the tissues. A single dose as described has a duration of approximately 1 h and it is only after this time that satisfactory antagonism can be obtained. The potency of pancuronium when compared with tubocurarine in the study is 6:1, from birth to 28 days.
筒箭毒碱以单次推注给药时，可安全用于新生儿的神经肌肉阻滞。推荐剂量在出生时为250μg/kg，28日龄时增至500μg/kg。如果出现早产、酸中毒或体温过低，或组织中存在某些抗生素或吸入麻醉剂时，应减少该剂量。所述的单次剂量持续时间约为1小时，只有在此时间之后才能获得满意的拮抗效果。在该研究中，从出生到28天，泮库溴铵与筒箭毒碱相比的效价为6:1。
