Mirakhur R K, Gibson F M, Ferres C J
Anesth Analg. 1985 Jul;64(7):711-4.
To evaluate possible potentiation of neuromuscular blocking effect of a combination of vecuronium and d-tubocurarine, cumulative dose-response curves were constructed to compare the potency of this combination with vecuronium and d-tubocurarine given alone. Ten patients each were given incremental injections of 80 micrograms/kg d-tubocurarine or 5 micrograms/kg vecuronium plus 40 micrograms/kg d-tubocurarine, the data for incremental administration of 10 micrograms/kg vecuronium being used from our previously published study (7). The results showed the combination of vecuronium plus d-tubocurarine to be significantly more potent (P less than 0.05) than would be expected from a simple additive effect of the individual drugs given alone. The ED95 doses of d-tubocurarine and vecuronium were 530 micrograms/kg and 57 micrograms/kg, respectively, when administered alone, but when administered together, the ED95 doses were 160 and 20 micrograms/kg, respectively.
为评估维库溴铵与d -筒箭毒碱联合使用时神经肌肉阻滞效应可能的增强作用，构建了累积剂量 - 反应曲线，以比较该联合用药与单独使用维库溴铵和d -筒箭毒碱的效价。分别给10例患者递增注射80微克/千克d -筒箭毒碱或5微克/千克维库溴铵加40微克/千克d -筒箭毒碱，递增注射10微克/千克维库溴铵的数据取自我们之前发表的研究（7）。结果显示，维库溴铵加d -筒箭毒碱的联合用药效价比单独使用各药物简单相加的预期效价显著更高（P小于0.05）。单独给药时，d -筒箭毒碱和维库溴铵的ED95剂量分别为530微克/千克和57微克/千克，但联合给药时，ED95剂量分别为160微克/千克和20微克/千克。
