Gibson F M, Mirakhur R K
Eur J Anaesthesiol. 1987 Mar;4(2):143-7.
Dose-response curves for pancuronium and tubocurarine were constructed using single-dose and cumulative-dose methods of administration. The dose-response curves for pancuronium were similar using the two methods, and resulted in an ED95 (dose required to produce 95% block of the twitch height) of 60 and 59 micrograms kg-1 using single-dose and cumulative-dose methods respectively. Although the dose-response curves for tubocurarine differed in their slopes and intercepts (significantly (P less than 0.01) for intercepts), the magnitudes of the ED95, 449 and 529 micrograms kg-1 respectively, were not significantly different. A cumulative-dose method for determination of the potency (ED95) of relatively long-acting drugs, such as pancuronium and tubocurarine, gives results which are similar to those obtained using a single bolus method, but has the advantage of requiring fewer subjects.
使用单次给药法和累积给药法构建了泮库溴铵和筒箭毒碱的剂量-反应曲线。两种方法所得泮库溴铵的剂量-反应曲线相似，单次给药法和累积给药法测得的产生95%颤搐高度阻滞所需剂量（ED95）分别为60和59微克/千克。虽然筒箭毒碱的剂量-反应曲线斜率和截距不同（截距差异显著（P<0.01）），但ED95值分别为449和529微克/千克，差异不显著。对于泮库溴铵和筒箭毒碱等作用时间相对较长的药物，采用累积给药法测定效能（ED95），所得结果与单次推注法相似，但优点是所需受试者较少。
