Lepkifker E, Lewin L M
Biomedicine. 1976 Dec 30;25(10):368-71.
A simple, semiquantitative paper chromatographic method was used to identify samples of cerebrospinal fluid containing elevated concentrations of myo-inositol. All patients whose CSF inositol concentrations were greater than 70 mug/ml (as determined by S. carlsbergensis microbiological assay) showed disturbances of the state of consciousness, reported as stupor, coma or confusion in adults, or apathy and stupor in infants. An elevated level of inositol in cerebrospinal fluid appeared to be a characteristic finding in infants under one year of age. Among other age groups no common etiology was correlated with high inositol concentration.
采用一种简单的半定量纸色谱法来鉴定肌醇浓度升高的脑脊液样本。所有脑脊液肌醇浓度大于70微克/毫升（通过卡尔酵母微生物测定法测定）的患者均出现意识状态障碍，成人表现为昏迷、昏睡或意识模糊，婴儿则表现为淡漠和昏睡。脑脊液中肌醇水平升高似乎是一岁以下婴儿的一个特征性表现。在其他年龄组中，高肌醇浓度与任何常见病因均无关联。
