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[脾脏与骨髓再生对小鼠脾脏造血集落数量的影响]

[Effect of spleen and bone marrow regeneration on the number of hematopoietic colonies in mouse spleen].

作者信息

Sukhova G K, Podrabinek T R, Kharlova G V

出版信息

Biull Eksp Biol Med. 1976;82(11):1375-6.

PMID:1016726
Abstract

The spleen (2/3) was removed in CBA male mice (the 1st group); in the 2nd group the bone marrow from the right posterior shin was removed. The hemopoietic splenic colonies were counted on the 8th day after the lethal irradiation and injection of 1 X 10(-6) nucleated cells of the intact spleen. A significant increase of the number of colonies in comparison with their number in control intact mice was observed. The authors suppose that this increase could also be caused by the local influence of the regenerating stroma of the spleen and by some stimulating factor discharge by the regenerating hemopoietic tissue.

摘要

切除CBA雄性小鼠的脾脏(切除2/3)(第一组);第二组切除右后肢胫骨的骨髓。在致死性照射并注射1×10⁻⁶个完整脾脏的有核细胞后的第8天,对脾造血集落进行计数。观察到与对照完整小鼠相比,集落数量显著增加。作者推测这种增加也可能是由脾脏再生基质的局部影响以及再生造血组织释放的某些刺激因子引起的。

相似文献

1
[Effect of spleen and bone marrow regeneration on the number of hematopoietic colonies in mouse spleen].[脾脏与骨髓再生对小鼠脾脏造血集落数量的影响]
Biull Eksp Biol Med. 1976;82(11):1375-6.
2
[Effect of regeneration of hematopoietic organs on the number and type of splenic colonies].[造血器官再生对脾集落数量和类型的影响]
Biull Eksp Biol Med. 1978 Feb;85(2):219-21.
3
Shielding of the thymic region during X-irradiation: effect on haemopoiesis in mice.X射线照射期间胸腺区域的屏蔽:对小鼠造血作用的影响。
Folia Biol (Praha). 1982;28(6):415-25.
4
[Mechanism of action of the stem-cell inhibition factor on the formation of exogenous hemopoietic colonies in the spleen of mice].
Biull Eksp Biol Med. 1984 Sep;98(9):326-9.
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Radiation sensitivity of hemopoietic stroma: long-term partial recovery of hemopoietic stromal damage in mice treated during growth.造血基质的辐射敏感性:生长期间接受治疗的小鼠造血基质损伤的长期部分恢复
Radiat Res. 1987 Feb;109(2):330-41.
6
Splenic thrombopoiesis after bone marrow ablation with radiostrontium: a murine model.用放射性锶进行骨髓消融后脾脏的血小板生成:一种小鼠模型。
J Lab Clin Med. 1990 Dec;116(6):879-88.
7
[Cells that maintain long-term hematopoiesis in culture do not possess the capacity for regeneration following irradiation].在培养中维持长期造血的细胞在受到辐射后不具备再生能力。
Biull Eksp Biol Med. 1987 Jul;104(7):96-9.
8
Studies of the hemopoietic microenvironments. V. Changes in murine splenic and bone marrow glycosaminoglycans during post irradiation hemopoietic regeneration.
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9
Use of spleen organ cultures in the analysis of hemopoietic alterations induced by irradiation and allogeneic marrow transplantation.脾脏器官培养在分析辐射和同种异体骨髓移植诱导的造血改变中的应用。
Exp Hematol. 1983 Jan;11(1):32-42.
10
[Effect of the dose of injected hematopoietic cells on the number of daughter splenic colony-forming cells in spleen colonies].[注射造血细胞剂量对脾集落中脾集落形成细胞子代数量的影响]
Biull Eksp Biol Med. 1986 Mar;101(3):349-50.