Moolten F, Capparell N, Boger E
J Natl Cancer Inst. 1978 Nov;61(5):1347-9. doi: 10.1093/jnci/61.5.1347.
Male inbred A/J mice immunized by combined ip and intranasal administration of a bovine serum albumin conjugate of 5-fluoro-12-methylbenzanthryl-7-acetic acid developed tracheal antibodies capable of binding the carcinogen benzo[a]pyrene (BP). Immunized mice administered 92 ng of [3H]BP intranasally exhibited a one-third reduction in BP content in respiratory tract tissues (nose and trachea) when compared with control mice 20 hours after BP administration.
通过腹腔注射和鼻内联合给予5-氟-12-甲基苯并蒽-7-乙酸的牛血清白蛋白偶联物免疫的雄性近交A/J小鼠产生了能够结合致癌物苯并[a]芘（BP）的气管抗体。与对照小鼠相比，在鼻内给予92 ng [3H]BP的免疫小鼠在给予BP后20小时，呼吸道组织（鼻子和气管）中的BP含量降低了三分之一。
