Kristufek P, Virsik K, Bajan A, Badalik L, Dreviankova V
Bull Eur Physiopathol Respir. 1976 May-Jun;12(3):467-75.
Functional data were collected from 5,746 males from a country region, whose ages ranged from 14 to 65 years. Out of this population we excluded a group of 466 males (9%) who had abnormal results of traditional pulmonary function screening tests (FVC less than 80% reference values or FEV1% FVC less than 70%) and chose a group of 1,092 males (19%) with normal values for the above two parameters but with abnormal forced mid-expiratory flow. In randomly selected persons of the second group we found frequency dependent dynamic compliance (100%), abnormal maximum expiratory flow at 25% of vital capacity (98%), increased residual volume (76%), decreased maximum expiratory flow at 50% of vital capacity (67%), and increased closing capacity (57%); on the contrary static complicane and airway resistance were normal. To account for these results we suppose that measurement of forced mid-expiratory flow, abnormal values of which we obtained in practically one fifth of the experimental population, could represent, in agreement with other reports, a suitable screening test for first or early detection of airway abnormalities.
从一个乡村地区的5746名男性中收集了功能数据，他们的年龄在14岁至65岁之间。在这一人群中，我们排除了一组466名男性（9%），他们的传统肺功能筛查测试结果异常（用力肺活量（FVC）低于参考值的80%或第一秒用力呼气容积占用力肺活量的百分比（FEV1%FVC）低于70%），并选择了一组1092名男性（19%），他们上述两个参数的值正常，但用力呼气中期流速异常。在第二组随机选择的人员中，我们发现频率依赖性动态顺应性（100%）、肺活量25%时最大呼气流量异常（98%）、残气量增加（76%）、肺活量50%时最大呼气流量降低（67%）以及闭合气量增加（57%）；相反，静态顺应性和气道阻力正常。为了解释这些结果，我们假设，与其他报告一致，用力呼气中期流速的测量（我们在几乎五分之一的实验人群中获得了其异常值）可能是首次或早期检测气道异常的合适筛查测试。
