von Oepen R, Michaeli W
Institut für Kunststoffverarbeitung, Aachen, Germany.
Clin Mater. 1992;10(1-2):21-8. doi: 10.1016/0267-6605(92)90080-d.
In medical engineering, degradable polymers represent an attractive alternative for conventional materials to be used as implants in the body. They are used as drug deliveries or as plates and screws to fix broken bones. Since they are completely broken down by the human body, the second operation, which is generally required, can be avoided. A central problem is the processing of these polymers, because no stabilisers are allowed. This causes a partially relevant loss in molecular weight, which correlates directly with the mechanical properties. Tests carried out on an injection moulding machine and on a conical plate rheometer show the influence of temperature, shear, residence time and moisture on molecular weight reduction and mechanical properties.
在医学工程领域，可降解聚合物是传统材料作为体内植入物的一种有吸引力的替代品。它们被用作药物递送载体或用于固定骨折的钢板和螺钉。由于它们会被人体完全分解，因此通常所需的二次手术可以避免。一个核心问题是这些聚合物的加工，因为不允许使用稳定剂。这会导致分子量出现部分相关损失，而分子量直接与机械性能相关。在注塑机和锥形板流变仪上进行的测试表明了温度、剪切、停留时间和水分对分子量降低和机械性能的影响。
