Coombes A G, Heckman J D
Department of Orthopaedics, University of Texas, Health Science Centre, San Antonio 78284.
Biomaterials. 1992;13(4):217-24. doi: 10.1016/0142-9612(92)90187-s.
A gel casting technique based on resorbable, synthetic, alpha-polyesters (or lactide-glycolide polymers) is described for producing medical implants such as bone graft substitutes and timed-release carriers for medication. This solution-based method enables production of thick-section solid and microporous materials, and blending of polymers and particulate fillers. Implant degradation rate, for example, may be adjusted by variation of polymer type, molecular weight range, crystallinity and morphology. Gel casting conditions are reported for solid and microporous materials and processing characteristics are interpreted in terms of established crystallization and dissolution behaviour of polymers.
描述了一种基于可吸收合成α-聚酯（或丙交酯-乙交酯聚合物）的凝胶浇铸技术，用于生产诸如骨移植替代物和药物定时释放载体等医用植入物。这种基于溶液的方法能够生产厚截面的固体和微孔材料，并能实现聚合物与颗粒填料的混合。例如，植入物的降解速率可通过改变聚合物类型、分子量范围、结晶度和形态来调节。报告了固体和微孔材料的凝胶浇铸条件，并根据聚合物已确定的结晶和溶解行为来解释加工特性。
