Amecke B, Bendix D, Entenmann G
Chemicals Division, Boehringer Ingelheim KG, Germany.
Clin Mater. 1992;10(1-2):47-50. doi: 10.1016/0267-6605(92)90084-7.
Synthetic polymers, in particular polyesters based on lactic acid, glycolic acid and other raw materials are described for medical and technical applications. Their main advantages are compatibility and safety. As they are degradable in the human body they are particularly suitable for implants needed only temporarily for the healing process. Resorbable polyesters are produced by direct polycondensation or ring opening polymerization resulting in a broad range of polymers with different features. The main properties such as degradation (hydrolytic and thermal), crystallinity and mechanical strengths are discussed. These polyesters, which can be processed like other thermo-plastic polymers by extrusion and injection moulding, are used mainly for wound closure products (sutures, staples, clips), fracture fixation devices (nails, screws, plates) and parenteral depot systems for the sustained release of drugs. Possibilities for polymer and process improvement to develop better implants and additional applications are presented.
描述了用于医学和技术应用的合成聚合物，特别是基于乳酸、乙醇酸和其他原料的聚酯。它们的主要优点是兼容性和安全性。由于它们可在人体中降解，因此特别适用于仅在愈合过程中临时需要的植入物。可吸收聚酯通过直接缩聚或开环聚合生产，从而产生具有不同特性的多种聚合物。讨论了诸如降解（水解和热降解）、结晶度和机械强度等主要性能。这些聚酯可以像其他热塑性聚合物一样通过挤出和注塑进行加工，主要用于伤口闭合产品（缝线、吻合钉、夹子）、骨折固定装置（钉子、螺钉、钢板）以及用于药物缓释的肠胃外长效注射系统。还介绍了改进聚合物和工艺以开发更好的植入物及其他应用的可能性。
