Suhonen R
Contact Dermatitis. 1976 Oct;2(5):264-8. doi: 10.1111/j.1600-0536.1976.tb03046.x.
Methoxsalen (8-methoxypsoralen) was used as the photoxic substance in the study of the properties of various vehicles in photoepicutaneous testing. Macrogols as such were relatively poor bases, and positive reactions were seen only occasionally at a concentration of 0.05% methoxsalen. Increasing amounts of water in macrogols brought forth more numerous and stronger reactions. The photoxicity also increased when ethanol was added. The reactions were, however, weaker than to those with aqueous bases. Wool fat and glycerol as vehicles usually reacted in the same way as polyethylene glycols when water was added. An explanation of the mechanism of the changes in the properties of vehicles due to the addition of water/ethanol requires further investigation.
甲氧沙林（8-甲氧基补骨脂素）在光皮肤试验中作为光毒性物质用于研究各种赋形剂的性质。聚乙二醇本身作为赋形剂时表现相对较差，在甲氧沙林浓度为0.05%时仅偶尔出现阳性反应。聚乙二醇中加入的水量增加会引发更多、更强的反应。加入乙醇时光毒性也会增加。然而，这些反应比在水性赋形剂中的反应要弱。羊毛脂和甘油作为赋形剂，加水后通常与聚乙二醇的反应方式相同。关于因加水/乙醇导致赋形剂性质变化的机制，还需要进一步研究。
