Zaynoun S T, Johnson B E, Frain-Bell W
Contact Dermatitis. 1977 Oct;3(5):225-39. doi: 10.1111/j.1600-0536.1977.tb03667.x.
Using a standardized open photopatch test technique, the phototoxic reactions produced by bergamot oil bergapten (5-methoxypsoralen) the active component of the oil, and xanthotoxin (8-methoxypsoralen) were studied. The reaction was affected by a range of factors such as the vehicle (PMF or ethanol), the concentration of ethanol in the vehicle, the skin site, the interval between application of the psoralen and irradiation, the hydration of the skin, and the degree of natural or sun-induced pigmentation. Repeated photopatch testing at the same skin site produced an increase in sensitivity. Eye colour, natural susceptibility to suntanning, age, and sex, had no effect on the phototoxic response to psoralens.
采用标准化的开放性光斑贴试验技术，对佛手柑油、其活性成分补骨脂素（5-甲氧基补骨脂素）和花椒毒素（8-甲氧基补骨脂素）所产生的光毒性反应进行了研究。该反应受多种因素影响，如赋形剂（丙二醇单甲醚或乙醇）、赋形剂中乙醇的浓度、皮肤部位、补骨脂素涂抹与照射之间的间隔时间、皮肤的水合作用以及自然或阳光诱发的色素沉着程度。在同一皮肤部位重复进行光斑贴试验会导致敏感性增加。眼睛颜色、自然晒黑易感性、年龄和性别对补骨脂素的光毒性反应没有影响。
