Suhonen R
Contact Dermatitis. 1976 Aug;2(4):218-26. doi: 10.1111/j.1600-0536.1976.tb03030.x.
The effects of various vehicles, the occlusion time and the concentration of the test substances on the phototoxic reactions were studied using the Finn Chamber method in photoepicutaneous testing, with methoxsalen and coal tar as test substances. Petrolatum proved to be a suitable base for methoxsalen and carbowax for coal tar. The optimal concentration of coal tar was 5% and that of methoxalen 0.03-0.05%. The optimal occlusion time for methoxsalen was 1-2 hours and for coal tar 24 hours. It was concluded that in order to obtain the most reliable results, these parameters should be determined separately for every photosensitizing compound to be tested.
在光皮肤试验中，采用芬兰小室法，以甲氧沙林和煤焦油作为受试物，研究了各种赋形剂、封闭时间和受试物浓度对光毒性反应的影响。凡士林被证明是甲氧沙林的合适基质，而聚乙二醇是煤焦油的合适基质。煤焦油的最佳浓度为5%，甲氧沙林的最佳浓度为0.03 - 0.05%。甲氧沙林的最佳封闭时间为1 - 2小时，煤焦油的最佳封闭时间为24小时。得出的结论是，为了获得最可靠的结果，对于每种待测试的光敏化合物，应分别确定这些参数。
