2-苯乙胺的代谢情况以及抑郁在美沙酮依赖和戒毒患者中的作用。

Metabolic disposition of 2-phenylethylamine and the role of depression in methadone-dependent and detoxified patients.

作者信息

Inwang E E, Primm B J, Jones F L, Dekirmenjian H, Davis J M, Henderson C T

出版信息

Drug Alcohol Depend. 1976 Apr;1(4):295-303. doi: 10.1016/0376-8716(76)90025-9.

Abstract

We have now postulated that differences in the innate capacity of individuals to synthesize, store and utilize biogenic amines may provide the biological basis for human abuse of narcotic and other drugs, and that these drugs are used in an apparent unconscious effort to self-medicate against an inherent affective disorder. In this communication, we attempted a preliminary characterization of the narcotics withdrawal syndrome on biochemical and clinical parameters. Abstinence was found to be characterized by low urinary excretion of 2-phenylethylamine and depression. An indication for use of tricyclic drugs has been discussed.

摘要

我们现在推测，个体在合成、储存和利用生物胺的先天能力上的差异，可能为人类滥用麻醉品和其他药物提供生物学基础，并且这些药物的使用显然是一种无意识的自我治疗行为，以对抗内在的情感障碍。在本报告中，我们试图根据生化和临床参数对麻醉品戒断综合征进行初步描述。研究发现，戒断的特征是2-苯乙胺的尿排泄量低和抑郁。文中还讨论了使用三环类药物的指征。