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大鼠对酒精的动机:位置和瓶子偏好不会导致饮酒。

Motivation for alcohol in rats: position and bottle preferences do not cause drinking.

作者信息

Sinclair J D

出版信息

Drug Alcohol Depend. 1976 Jun;1(5):357-66. doi: 10.1016/0376-8716(76)90038-7.

DOI:10.1016/0376-8716(76)90038-7
PMID:1017380
Abstract

Position preference, i.e., the tendency to drink from onelocation rather than the other, was found to be relatively unimportant in determining the drinking behavior of rats presented with a choice between water and a 7% (v/v) ethanol solution in typical two-bottle choice situations. It accounted for essentially none of the variance in rats generally drinking more alcohol solution than water after prolonged previous alcohol experience, and in rats consuming very little alcohol; only in rats drinking slightly less alcohol solution than water was it found to have an influence. Similarly, bottle preference, i.e., the tendency to drink from one of the two bottles regardless of its position or contents, andposition preference were found to have almost no effect on heavy-drinking rats even on their first day of exposure and on low-drinking rats after about three days of access to alcohol.

摘要

在典型的双瓶选择情境中,当给大鼠提供水和7%(体积/体积)乙醇溶液供其选择时,位置偏好(即倾向于从一个位置而非另一个位置饮水)在决定大鼠的饮水行为方面相对不重要。对于先前有长期饮酒经历后通常饮用酒精溶液比水多的大鼠,以及饮酒量极少的大鼠,位置偏好基本不影响其饮酒差异;只有在饮用酒精溶液比水略少的大鼠中,才发现位置偏好有影响。同样,瓶子偏好(即不管瓶子位置或内容物如何,倾向于从两个瓶子中的一个饮水)和位置偏好,即使在重度饮酒大鼠接触酒精的第一天,以及在给予酒精约三天后的轻度饮酒大鼠中,也几乎没有影响。

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