Graeff H, Ernst E, Bocaz J A, von Hugo R, Hafter R
Haemostasis. 1976;5(5):285-94. doi: 10.1159/000214147.
Soluble fibrin monomer complexes (SFMC) were determined in patients with septic abortion (body temperatures of more than 39 degree C and/or chills without apparent signs of endotoxic shock), with infected abortion, with non-infected abortion and with normal pregnancies. Quantitative gel filtration (4% agarose) of beta-alanine precipitated plasma samples yielded the relative (percent of total fibrinogen content) and absolute (mg/100 ml plasma) amount of SFMC. The relative (5.5+/-1.4%, mean+/-SD) and absolute (21.5+/-8.6 mg/100 ml) amount of SFMC was significantly increased in patients with septic abortion compared to patients with normal pregnancies or non-infected abortion (p less than 0.001). Patients with infected abortion (p less than 0.001). Patients with infected abortion already revealed increased levels of SFMC (4.3+/-1.2%, 14.2+/-6.8 mg/100 ml) though their platelet count was still unaltered (infected abortion: 221+/-47 X 10(3) platelets/mm3; septic abortion; 99+/-36 X 10(3) platelets/mm3). The use of heparin in patients with septic abortion resulted in a decrease in SFMC. Chain characterization of SFMC frequently revealed a slight degradation of the alpha-chains probably due to fibrinolytic activity in vivo; gamma-gamma dimers representing intermolecular covalent bindings were not observed. The findings are in agreement with our former assumption that patients with septic abortion have a pronounced state of hypercoagulability.
对患有感染性流产（体温超过39摄氏度和/或寒战但无明显内毒素休克迹象）、感染性流产、非感染性流产及正常妊娠的患者测定可溶性纤维蛋白单体复合物（SFMC）。对β-丙氨酸沉淀的血浆样本进行定量凝胶过滤（4%琼脂糖），得出SFMC的相对量（占总纤维蛋白原含量的百分比）和绝对量（mg/100ml血浆）。与正常妊娠或非感染性流产的患者相比，感染性流产患者的SFMC相对量（5.5±1.4%，均值±标准差）和绝对量（21.5±8.6mg/100ml）显著增加（p<0.001）。感染性流产患者（p<0.001）。感染性流产患者的SFMC水平已升高（4.3±1.2%，14.2±6.8mg/100ml），尽管其血小板计数仍未改变（感染性流产：221±47×10³个血小板/mm³；感染性流产：99±36×10³个血小板/mm³）。对感染性流产患者使用肝素导致SFMC减少。SFMC的链特征分析经常显示α链可能因体内纤溶活性而略有降解；未观察到代表分子间共价结合的γ-γ二聚体。这些发现与我们之前的假设一致，即感染性流产患者具有明显的高凝状态。
