Graeff G, Wiedemann A, von Hugo R, Hafter R
Am J Obstet Gynecol. 1976 Jan 1;124(1):21-4. doi: 10.1016/0002-9378(76)90005-3.
Soluble fibrin monomer complexes (SFMC) were determined in 12 patients following delivery, 2, 4, 6 days and 3 months post partum. Quantitative gel filtration (1 per cent agarose) of the beta-alanine-precipitated plasma samples yielded the relative (per cent of the total fibrinogen content) and absolute (milligrams per 100 ml. of plasma) amount of SFMC. During the early puerperium the amount of SFMC remained essentially constant, with average postpartum values of 6.3 +/- 1.2 per cent and 27.6 +/- 9.1 mg. per 100 ml. (mean and standard deviation). Three months after delivery the level of SFMC was significantly (p less than 0.001) decreased (3.3 +/- 1.3 per cent and 8.4 +/- 3.4 mg. per 100 ml.). The quantitative estimation of SFMC in the early puerperium as presented in this study indicates that a state of hypercoagulability can be evaluated by measuring the thrombin-mediated catabolic products of fibrinogen.
在12名产后妇女产后2天、4天、6天及3个月时测定可溶性纤维蛋白单体复合物（SFMC）。对经β-丙氨酸沉淀的血浆样本进行定量凝胶过滤（1%琼脂糖），得出SFMC的相对含量（占纤维蛋白原总含量的百分比）和绝对含量（每100毫升血浆中的毫克数）。在产褥早期，SFMC含量基本保持恒定，产后平均值为6.3±1.2%和每100毫升27.6±9.1毫克（均值和标准差）。分娩3个月后，SFMC水平显著降低（p<0.001）（每100毫升3.3±1.3%和8.4±3.4毫克）。本研究中对产褥早期SFMC的定量评估表明，通过测量凝血酶介导的纤维蛋白原分解产物可评估高凝状态。
