Zweiman B, Slott R I, Atkins P C
Int Arch Allergy Appl Immunol. 1976;52(1-4):48-52. doi: 10.1159/000231666.
Factors underlying the eosinophil responses in the tissue sites of immediate hypersensitivity reactions have been investigated. A quantitative assessment of the number of eosinophils appearing in skin test reactions to ragweed antigen and compound 48/80 in ragweed-sensitive humans has been compared with several other parameters. There was a moderate, statistically significant, correlation with serum levels of IgE-class antiragweed antibody; also, eosinophil responses were minimal or absent in minimally positive threshold dilution skin tests. Tissue eosinophil responses were generally limited to those with baseline blood eosinophil levels of at least 150 mm3; however, there was no correlation between blood and tissue eosinophil levels in individual subjects. These findings suggest that the pathogenesis of the observed tissue eosinophil responses may be multifactorial.
对速发型超敏反应组织部位嗜酸性粒细胞反应的潜在因素进行了研究。已将豚草敏感人群中对豚草抗原和化合物48/80的皮肤试验反应中出现的嗜酸性粒细胞数量的定量评估与其他几个参数进行了比较。与IgE类抗豚草抗体的血清水平存在中度的、具有统计学意义的相关性；此外，在最低阳性阈值稀释皮肤试验中，嗜酸性粒细胞反应最小或不存在。组织嗜酸性粒细胞反应通常仅限于那些基线血嗜酸性粒细胞水平至少为150/mm³的情况；然而，个体受试者的血液和组织嗜酸性粒细胞水平之间没有相关性。这些发现表明，观察到的组织嗜酸性粒细胞反应的发病机制可能是多因素的。
