Dunsky E H, Atkins P C, Zweiman B
J Allergy Clin Immunol. 1977 Feb;59(2):142-6. doi: 10.1016/0091-6749(77)90216-0.
A controlled study has been carried out dealing with the early effects of a single intravenous dose of either methylprednisolone or placebo or newly developed and ongoing cellular inflammatory responses in immediate hypersensitivity skin test reactions. There was no significant difference in the tissue eosinophil responses to ragweed injected 2 hr before and 2 hr after placebo; there was a significant rise (101% +/- 39) from the second to fourth hour after antigen injection. By contrast, there was a marked decrease in the tissue eosinophil response to antigen injected 2 hr after steroids as compared to the pattern seen in the presteroid reaction. In addition, the eosinophil numbers not only did not increase from the second to fourth hour when steroids were injected at the second hour but decreased markedly. These findings suggest early suppressive effects on tissue eosinophil responses within 2 hr after steroid were administered intravenously. Also, there may be trafficking of eosinophils both into and out of these inflammatory sites during the first hours after intradermal antigen injection.
一项对照研究已开展，旨在探讨单次静脉注射甲泼尼龙或安慰剂后早期的影响，以及新出现的和持续存在的细胞炎症反应在速发型超敏皮肤试验反应中的情况。在安慰剂注射前2小时和注射后2小时，对豚草的组织嗜酸性粒细胞反应无显著差异；抗原注射后第二至第四小时有显著升高（101%±39）。相比之下，与注射类固醇前反应的模式相比，注射类固醇后2小时注射抗原的组织嗜酸性粒细胞反应明显降低。此外，当在第二小时注射类固醇时，嗜酸性粒细胞数量不仅在第二至第四小时没有增加，反而明显减少。这些发现表明，静脉注射类固醇后2小时内对组织嗜酸性粒细胞反应有早期抑制作用。此外，在皮内注射抗原后的最初几个小时内，嗜酸性粒细胞可能会进出这些炎症部位。
