Mertz D P
MMW Munch Med Wochenschr. 1978 Oct 20;120(42):1387-90.
The daily administration of 25 mg effervescent granules is about equipotent with a daily dose of 200 mg allopurinol, giving due attention to the caution necessary for uricosuric therapy. The daily administration of 50 mg benzbromarone effervescent granules has a slight but significantly greater uric acid-lowering effect than treatment with 300 mg allopurinol per day. The tolerance of benzbromarone in the active form named was good in all cases. Side effects were not observed. Since benzbromarone as effervescent granules is taken with plenty of fluid this takes care of an increased fluid intake and introduces a motivation for doing so.
每日服用25毫克泡腾颗粒的效果与每日服用200毫克别嘌醇大致相当，同时要充分注意促尿酸排泄疗法所需的注意事项。每日服用50毫克苯溴马隆泡腾颗粒的降尿酸效果比每日服用300毫克别嘌醇略有增强，但差异显著。在所有病例中，上述活性形式的苯溴马隆耐受性良好，未观察到副作用。由于苯溴马隆泡腾颗粒需与大量液体一起服用，这有助于增加液体摄入量，并且提供了这样做的动力。
