Mertz D P
MMW Munch Med Wochenschr. 1978 Oct 27;120(43):1419-24.
Under physiological conditions there is satisfactory agreement between the clearance values of endogenous creatinine and inulin in humans. In chronic renal insufficiency the endogenous creatinine clearance cannot be considered as an index for glomerular filtrate because of considerable individual variations. In spite of this limitation endogenous creatinine clearance proves to be a sensitive test for hospital and general practice to estimate the loss of renal function in chronic progressive renal diseases if the loss of function has not yet led to an increase of the serum creatinine concentration.
在生理条件下，人体内源性肌酐清除率与菊粉清除率的值之间存在令人满意的一致性。在慢性肾功能不全时，由于个体差异较大，内源性肌酐清除率不能被视为肾小球滤过率的指标。尽管存在这一局限性，但如果肾功能丧失尚未导致血清肌酐浓度升高，内源性肌酐清除率对于医院和普通诊所评估慢性进行性肾脏疾病的肾功能丧失而言，仍是一项敏感的检测方法。
