van den Heever L W
J S Afr Vet Assoc. 1976 Dec;47(4):257-61.
A series of 152 quarters affected with subclinical staphylococcal and streptococcal mastitis was treated at random by intramammary infusion with one of 4 formulations containing inert solvent, specially prepared immunoglobulin (Ig) and antibiotics (penicillin G and streptomycin) in various combinations. The effect of treatment was measured by assessing the conversion of mastitic quarters to a normal or mastitis-negative state over a post-treatment period of 28 days. Considering the solvent as a placebo, solvent plus Ig had no significantly better effect than solvent only; solvent plus antibiotics gave results that were highly significant after 14 days even though about a third of the strains of S. aureus were resistant in vitro to one or both of the antibiotics; solvent plus antibiotics and Ig gave results that were highly significant during the whole 4 weeks after treatment. The Ig solution appeared to be considerably more effective against staphylococcal than streptococcal mastitis, but the small numbers precluded statistical analyses. It was concluded that use of the particular batch of Ig alone had no value in the treatment of the common forms of subclinical bacterial mastitis but that in combination with antibiotics the Ig had a somewhat better effect than was obtained with antibiotics alone.
对152个患有亚临床葡萄球菌和链球菌性乳腺炎的乳腺象限进行了随机治疗，通过乳房内灌注4种制剂中的一种，这些制剂含有惰性溶剂、特别制备的免疫球蛋白（Ig）和抗生素（青霉素G和链霉素）的各种组合。通过评估在28天的治疗后乳腺象限转变为正常或无乳腺炎状态来衡量治疗效果。将溶剂视为安慰剂，溶剂加Ig的效果并不比仅用溶剂显著更好；溶剂加抗生素在14天后效果非常显著，尽管约三分之一的金黄色葡萄球菌菌株在体外对一种或两种抗生素耐药；溶剂加抗生素和Ig在治疗后的整个4周内效果都非常显著。Ig溶液对葡萄球菌性乳腺炎的效果似乎比对链球菌性乳腺炎显著更有效，但数量较少无法进行统计分析。得出的结论是，单独使用特定批次的Ig对常见形式的亚临床细菌性乳腺炎治疗没有价值，但与抗生素联合使用时，Ig比单独使用抗生素有稍好的效果。
